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SOPHiA GENETICS combines deep expertise in life sciences with mathematical capabilities in data computing to create the future of AI-assisted Medicine. As we pass 1,000,000 genomic profiles analyzed and look to the future of our platform, we are now searching for a principal engineer who will help in transitioning our platform to the next level. We are looking for Principal Software Engineer to join our team!

SOPHiA GENETICS (NASDAQ: SOPH) combines Data-Driven Medicine, Genomics and Radiomics, to ensure that the data used to help patients today will also benefit the patients of tomorrow. SOPHiA DDM™ Platform in supporting multimodal data-driven medicine.


You will have the opportunity to recommend and drive new initiatives and support our fast-growing organization. We are looking for a motivated, enthusiastic and flexible person with the capacity to work independently on projects to completion.

Our products are used by hundreds of healthcare institutions globally and provide world leading capabilities for the analysis of genomic, clinical, and imaging data.

The role is at our HQ, Rolle, Switzerland.

Therefore, if you’re a dynamic, self-motivated professional who believes nothing is impossible, love to learn and be curious, we’d love to have you as part of our team!



  • As a Principal Software Engineer, you will be the technical lead of a team of Engineers focused on developing web-modules and their microservices powering a multi-modal digital healthcare platform.
  • Our platform is a one-of-a-kind globally distributed information system that brings together hospitals and labs to provide data ingestion and processing, analysis, and modeling, reporting and intelligence, distribution and sharing of a multitude of complex sources of structured and unstructured data, including genomics, imaging, and clinical data, delivered as a multi-tenant SaaS platform on the cloud.
  • You will be performing end-to-end delivery of web-modules on our digital platform, guiding a team of engineers with best practices, and helping make architectural decision as part of our Software Development Lifecycle. This will include design, implementation, testing, documentation, deployment, maintenance, and support of the services and other projects owned by the team.
  • You will be responsible for the design of individual components of these modules and will collaborate daily with product owners and senior technical staff outside of the team.
  • You will participate in the evaluation of new technologies and implement POCs for future modules.
  • You will actively participate in code and design reviews with other members of the team.
  • As needed for your projects, you will participate in estimations and risk assessments, and exchange with stakeholders in Product and Project Management and other departments.
  • You will participate in the team’s recurring activities and help organize them. You will share your knowledge of best practices in the team and support more junior team members.

Votre profil


  • You have demonstrated experience in developing reliable and performant full-stack applications and have a firm grasp on the underlying challenges of releasing a web module to production.
  • You have a basic understanding of the domain of genomics and digital healthcare and care for the impact you can have in this field.
  • You know modern software engineering processes, have good knowledge of tools, technologies, and best practices.
  • You seek to exchange regularly and communicate effectively with other members of your team.
  • Bachelor’s degree in computer science or engineering or equivalent professional experience
  • 8+ years’ experience in the software engineering field.
  • Demonstrated experience working on Service-Oriented Architectures, Microservices, and APIs,
  • Strong knowledge of Java, JavaScript/Typescript, and other languages,
  • Good knowledge of front-end framework like React, Vue.js, NextJs,
  • Good knowledge of modern DevOps tools,
  • Good knowledge of modern scalable database technologies and SQL,
  • Good knowledge of software engineering best-practices, Agile, CI/CD, testing frameworks, BDD, TDD, ...
  • Good interpersonal and communication skills,
  • Excellent level of English, French mandatory
  • Knowledge of GraphQL is a plus
  • Experience with containerization (Docker, ...) and orchestration (Kubernetes, ...) technologies is a plus,


  • A flexible, friendly and international working environment with a collaborative atmosphere
  • An exciting company mission that brings together science and technology to directly impact the lives of patients with life threatening illness.
  • A fast-growing company with plenty of opportunity for personal growth and development
  • A hard technical challenge to solve with exciting modern technology - cloud computing, Big Data, DevOps, machine learning
  • Competitive compensations and good benefits

Location: Rolle, Switzerland (ONSITE 3 days in the office)

Start: ASAP (or as agreed)

Contract type: permanent full-time

Diversity & Inclusion: As committed employer, SOPHiA GENETICS offers everyone the same opportunities to access employment regardless of gender, ethnicity, religion, sexual orientation, social status, disability, or age. SOPHiA GENETICS strives to develop an inclusive work environment that reflects the diversity of its employees. All information will be treated confidentially in accordance with the Employment Equity Act.

Application Process: If you think you fit this position, please send a CV in English and a cover letter. Please note that incomplete applications will not be considered. After an initial screening process, candidates will be invited for remote interviews.

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